From the "Be Interesting" chapter of Never Eat Alone by Keith Ferrazzi and Tahl Raz:
3. Know yourself and your talents.
I had no chance competing with the science geeks at ICI. In developing an expertise that highlighted my strengths, I was able to overcome my weaknesses. The trick is not to work obsessively on the skills and talents you lack, but to focus and cultivate your strengths so that your weaknesses matter less. I'd apply the 80/20 rule in that you should spend some time getting better at your weaknesses but really focus on building your strengths.
Or, as I like to tell people, ride your horse in the direction it's going.